Notte-relax 30 tbl

THE BEST ANSWER TO INSOMNIA PROBLEMS

What is TN Pharma Notte-Relax and what is it used for?

Insomnia is a sleep disorder characterized by repeated difficulty with the initiation, duration, maintenance, or quality of sleep. The disorder is present despite the opportunity to obtain adequate conditions and amounts of sleep and is a subjective disorder, as it refers to difficulty falling asleep, maintaining sleep, or poor sleep quality.

• To classify insomnia as a true disorder, 3 criteria must be met: amount of time for falling asleep and waking up at night equal to or greater than 30 minutes;
• frequency equal to or greater than 3 nights per week;
• duration equal to or greater than 6 months.

Notte-Relax is a specific dietary supplement that helps reduce the time required to fall asleep, thereby also improving normal psychological function. Notte-Relax, based only on selected and patented natural ingredients, relieves sleep disorders, improving a person's well-being and quality of life.

TN Pharma'sNotte-Relax is also a certified GLUTEN-FREE product.

Why choose TN Pharma Notte-Relax?

Although insomnia is defined as a sleep disorder, it has repercussions that extend beyond the sleep period, significantly affecting the waking period and exhibiting different characteristics and symptoms: nighttime symptoms include difficulty initiating and/or maintaining sleep, light and non-restorative sleep; daytime symptoms include drowsiness, difficulty concentrating, decreased mood, irritability, and social/occupational difficulties. Insomnia is a persistent disorder but not necessarily consistent in symptoms and extent over time, and the causes by which it develops can be various and varying in magnitude, but first and foremost is definitely stress. The forms of treatment for Insomnia Disorder are drug therapy and cognitive-behavioral psychotherapy.

Before we get to drugs, however, the natural world provides us with a wide selection of extracts that can alleviate sleep disorders.

Let's see what the innovative ingredients in TN Pharma Night-Relax are:

LACTIUM®

Lactium® is a milk protein hydrolysate, with relaxing properties, designed to prevent and regulate problems and bad habits caused by stress: nervous hunger, smoking, mood swings, sexual problems, memory and concentration problems, and especially sleep disorders. An original and 100% natural answer, Lactium® is the ideal partner for stress management. It is a unique and innovative ingredient covered by an international patent that draws its origin from a simple observation: newborn babies are seen blissful and calm after ingesting milk; studies show that this calm state is not related to satiety and there is an idea that there is an element in milk that can calm newborn babies. After 10 years of research and numerous clinical studies, it was possible to identify, within a milk protein, a bio-peptide: alpha-casozepine, obtained by enzymatic digestion, with natural relaxing properties.
As adults lose enzymes over time that can metabolize milk and extract this peptide, the advantage of using Lactium®, which already contains this active peptide, arises.

How does Lactium® work?

Because it has a high affinity and selectivity for certain receptors in the brain called GABA-A receptors, Lactium® stimulates the activity of Gamma-Amino Butyric Acid (GABA), a neurotransmitter that inhibits anxiety and stress response at the brain level. This mechanism of action thus determines its relaxing properties.
It also enables the regulation of the body's mechanisms of stress adaptation and prevention. In other words, it allows the "good" stress level to be maintained naturally and effectively.
This ingredient has undergone six rigorous scientific studies on humans that led to the following conclusions:

• Anti-stress efficacy was confirmed at the dose of 150 mg per day;
• No undesirable effects were observed;
• No toxic effects were observed;
• Can be recommended for all people with symptoms of both occasional and constant stress.

RHODIOLIFE®

Rhodiolife® is a standardized extract of Rhodiola rosea roots with adaptogenic properties. Adaptogens are special types of natural substances that work on our bodies by making them adapt especially in situations of high stress and during particularly tiring times. Specifically, Rhodiolife® is a powerful adaptogen that produces a state of nonspecific resistance to physical, emotional, or environmental stresses. It has a normalizing effect on the body by helping to restore normal physiological function impaired by chronic stress. The adaptogenic activity of Rhodiolife® is attributed to the presence of two main active ingredients: salidroside and rosavin.

The mechanism of action of Rhodiola rosea constituents (particularly rosavin, which has greater biological activity) directly involves serotonin whose functions appear to be related to the control of appetite, sleep, behavior, mood, cardiovascular function, memory, and adaptive capacity. The therapeutic effect seems to be determined through inhibition of the enzyme responsible for inactivation of serotonin Catechol-O methyltransferase (COMT) and stimulation of the transport of 5-hydroxytryptophan (5HTTP), the precursor of serotonin, across the blood-brain barrier. The end result leads to an increase in serotonin levels in the blood, and this increase develops various effects including improved mood that results in improved sleep as well.

It is no secret that Rhodiola Rosea products on the market are numerous, but the TN Pharma Research & Development Team turned to the use of this patented specialty because of the high degree of purity and titer of the active ingredients it contains. The plants used for the extraction of Rhodiolife® are grown in the Siberian mountains protected from any source of pollution and harvested according to their biological cycle, keeping the entire supply chain under control.

VALEROSELECT®

Valeroselect® is a potent standardized and patented extract of Valeriana Officinalis. Valerian (Valeriana officinalis) is a plant in the Valerianaceae family widely used for the treatment of anxiety, states of agitation and sleep disorders.

The root of this plant, with its unmistakable unpleasant smell, contains essential oils and is itself composed of moterpene (mainly borneol derivatives) and sesquiterpene compounds (valerenic acid, valerenal acid, valeranone and beta-caryophyllene). Other active compounds contained in the plant are called valepotriates, some lignans and modest amounts of alkaloids.

The anxiolytic and sedative properties of valerian root are due to all of its constituents and, in particular, valerenic acids. These compounds are in fact capable of acting on GABAergic control mainly through inhibition of presynaptic GABA degradation and reuptake and promotion of synthesis by activation of an enzyme called glutamate decarboxylase.

Since GABA is an inhibitory-type neurotransmitter, substances that increase the activity of GABAergic synapses depress the activity of the central nervous system, resulting in a relaxing and anxiolytic effect.

Due to the presence of these active ingredients, Valeroselect® possesses sedative, relaxing, and hypnoinductive properties, and its administration can help over time to reduce symptoms related to anxiety and agitation and improve sleep time and duration.

EXCLAIM

Also known as California poppy, it is a natural remedy that can help our bodies relax and ease daily tensions to rediscover the benefits of healthy sleep.

Several types of molecules are present in the flowers ofeschscholzia, among which we find flavonoids, with antioxidant properties, and carotenoids, responsible for the characteristic deep orange color of these poppies.

• What are the properties of this plant? Eschscholzia promotes the relaxation of our bodies in cases of daily stress: at the end of a particularly busy day we often find ourselves with a load of stress that hinders our mental and physical well-being, which may not allow us to sleep well. Exams to pass, family worries, and non-stop work can test us, making it difficult to find some relaxation that reconciles sleep. California poppy facilitates relaxation by helping to improve our sleep;
• Thanks to California poppy we can take care of our rest. Going to bed late and sleeping too "lightly" are some of the consequences of daily commitments and tensions. When we go "into the wee hours," our bodies may have some difficulty getting through the falling asleep phase, which generally precedes the deep sleep phase in which the peak synthesis of melatonin, the sleep hormone, occurs. If we go to sleep after midnight, we may not be able to fully achieve deep and continuous sleep, risking waking up from even minor disturbances. California poppy promotes relaxation by helping to counteract annoying nighttime awakenings;
• Eschscholzia is a valuable ally against the fragmented sleep typical of old age: the synthesis of melatonin, or the sleep hormone, tends to decrease physiologically with advancing age, so the older we get, the less melatonin we produce. This slow change over the course of adult life can promote the appearance of discontinuous sleep with frequent nighttime awakenings. Escholzia can help us regain a healthy and restorative sleep by combating awakenings during the night hours.

All these properties can be attributed to the presence of alkaloids that act directly at the level of the central nervous system and are able to induce sleep.

PASSIFLORA

Passionflower-the scientific name Passiflora incarnata-is a perennial, climbing, branching herbaceous plant that possesses a stout, woody stem; native to the southeastern United States, Argentina and Brazil, it is known for its sedative properties.

Itproves to be a winning association between this plant, eschscholzia and valerian because all three have anxiolytic and sedative action but according to different mechanisms of action .

The chemical constituents contained in passionflower are many; among these, flavonoids (among which we find hyperoside, vitexin, and isovitexin) are of particular interest, as it is believed that the sedative properties attributed to the plant can be traced precisely to the presence of these substances.

Also of great importance are the indolic alkaloids (passiflorine, armine, etc.) believed to be responsible for the antispasmodic action ascribed to passionflower.

Other constituents include cyanogenetic glycosides, tannins, phytosterols and trace essential oil.

Because of its calming action, it is one of the most widely used phytotherapeutic remedies for mood and sleep disorders, and is the most suitable remedy in anxious-depressive forms; it exerts a sedative action without depressing the nervous system, is antispasmodic, hypnoinductive, antacid, counteracts cardiac erectism, and is effective in dry coughs of nervous origin.

Recent research has shown that flavonoids in passionflower are able to bind to cerebrospinal receptors for benzodiazepines, performing a targeted sedative and relaxing action that promotes relaxation and physiological sleep at night without causing daytime drowsiness. It is also free of narcotic effects and is nonaddictive.

To strengthen the potency of the product, the formula of NOTTE-RELAX has been supplemented with the addition of GABA (GammaAminoButyric Acid) whose action supports the mechanism of action of the other extracts.

NOTTE-RELAX represents a safe and effective ally for our insomnia problems with the advantage of also being gluten-free.

How to take TN Pharma Notte-Relax?

It is recommended to take 2 tablets daily, with a glass of water, just before bedtime