Vitamina d3 + k2 60 tbl
Supplement of vitamins D3 and K2, Cholecalciferol and Menaquinone, important for bone health. Vegan. Gluten Free. Lactose-free.
Dietary supplement for muscle growth, strength gain and fat loss, with a formula based on Mediator®: Phosphatidic Acid. Best muscle hypertrophy supplement.
VEGAN, GLUTEN-FREE and lactose-free.
Increasing muscle mass is the classic concept that is simple in theory but extremely difficult in practice. That training and nutrition are the two main aspects to be taken into account is a well-known fact, yet research in the field of supplementation over the years has always looked for natural substances that could increase muscle mass in a tangible way.
First and foremost we find creatine, a substance that promotes cell hydration, increases strength and endurance, as well as stimulates protein synthesis. The latter is also stimulated by the intake of protein powder, especially when taken around training. Or again, there is evidence that arginine and glutamine can promote protein synthesis and improve recovery between sessions.
However, there has always been a lack of an actual molecule exclusively dedicated to direct muscle growth, or rather, those that are known are not legal. In recent years, however, people have begun to investigate an element that could really make a difference, and Tsunami has decided to invest in it by bringing it to Italy first: Mediator®.
Tsunami Nutrition 'smTOR Pure PROFESSIONAL is a dietary supplement based on Mediator®: Phosphatidic Acid, a new generation product, present for the first time on the Italian market thanks to Tsunami Nutrition.
The most important and innovative feature of the patented Mediator® ingredient is that it is the only one in the world that can guarantee IMPORTANT MUSCULAR GROWTH, as certified by authoritative clinical studies.
mTOR Pure PROFESSIONAL, the best muscle hypertrophy supplement, thanks to the properties of the patented ingredient Mediator®, allows for twice the increase in muscle mass, strength, and twice the loss of fat mass in athletes and sportsmen who regularly practice weight training and follow a proper diet.
The mTOR (or mammalian target of rapamycin, target of rapamycin in mammals) is a protein kinase that integrates all information from nutrients (carbohydrates, lipids, proteins, fibers, water, vitamins, and minerals) and growth factors, i.e., proteins capable of stimulating cell proliferation and differentiation (IGF-1). This means that it is the protein that controls cell growth, metabolism, and durability. As it is therefore responsible for muscle growth, its stimulation leads to hypertrophy of myocells (muscle cells).
Mediator® is a trademark of phosphatidic acid, a membrane phospholipid derived from glycerol and precursor of other phospholipids such as phosphatidylserine and phosphatidylcholine. Recently it has been found that phosphatidic acid, when accompanied by mechanical stress (and thus overload training) and adequate protein intake, importantly activates the mTOR signaling pathway, which, as seen above, is the protein kinase responsible for muscle growth. In addition to this, further studies have shown that phosphatidic acid may even reduce catabolism, thereby decreasing muscle loss, as well as promoting muscle growth.
In 2012, Hoffman and colleagues studied phosphatidic acid intake and overload training in a double-blind study, that is, a study where one group takes the substance to be studied and the other a placebo, both without knowing which one they are taking. The results were clear right away: with the same amount of training (the same for both groups), the group taking phosphatidic acid increased muscle mass almost twice as much and reduced fat mass twice as much as the placebo group.
And again, in a second double-blind study, it was found that the group taking Mediator® increased muscle mass and strength as well as doubled the loss of fat mass compared to individuals consuming placebo.
Regarding the anticatabolic aspect (reduction of muscle loss), clinical studies were performed by analyzing genetics in vitro. It was seen how increased phosphatidic acid production by myocells leads to reduced muscle protein breakdown, thus reducing catabolism. In addition to this, it was noted how increased gene expression of phosphatidic acid interferes with the expression of myostatin, a major molecule responsible for muscle tissue loss. Scientists at Auburn University (USA) observed how a mix of phosphatidic acid and protein extremely increased protein synthesis and greatly reduced muscle catabolism.
There are many muscle growth enhancers on the market, however, and the "mere" fact that Mediator® was found to be extremely effective in the studies still does not allow us to understand how much more effective it is than others.
Hence the question arises: can it be substituted for much more studied and proven products, such as creatine, for example?
The answer is no, but let us analyze the question.
Creatine is undoubtedly an excellent supplement with hundreds of studies behind it, perhaps the best for power sports people, but it acts in a totally different way than phosphatidic acid: it is used to release and store energy, which is needed for many cellular processes (including protein synthesis). Phosphatidic acid, on the other hand, is a potent activator of mTOR, thereby accelerating muscle protein synthesis.
Since the clinical studies on Mediator® are all extremely positive, a winning strategy could certainly be to take both substances to exponentially increase the chances of muscle growth.
Studies have shown that taking Phosphatidic Acid allows a 12.7 percent increase in strength and a 2.6 percent increase in lean mass . Placebo-treated subjects, on the other hand, showed a 9.3% improvement in strength and a 0.1% change in lean mass gain.
The studies, moreover, found in those taking Mediator®: Phosphatidic Acid a doubling of muscle mass gain, an increase in strength, and a doubling of fat mass loss compared to individuals consuming placebo.
Full clinical studies on the efficacy of Mediator® can be viewed online:
Regarding Mediator®, clinical studies state that a safe and effective dose is 750mg/day to be taken daily.
Given its great efficacy in stimulating mTOR and the way it works, it is recommended to take it daily in the morning or before bedtime, and post-workout, preferably with a protein isolate shaker, on training days in order to increase the stimulation of protein synthesis to the highest levels for the following reasons:
Tsunami Nutrition 'smTOR Pure PROF ESSIONAL, best muscle hypertrophy supplement, can work synergistically with other supplements in our PROFESSIONAL line. Among these we definitely recommend:
Tsunami Nutrition KREALKAPure 120 cps, a buffered creatine supplement to increase strength, mass and recovery, certified VEGAN OK, GLUTEN FREE and LACTOSE FREE.
Tsunami Nutrition PEPTORECOVERY Pure 658 g, Supplement based on patented raw materials useful in post-workout nutrition. Which contains less than 0.2 g of lactose and is certified GLUTEN FREE.
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